Self-Seeding Microwells to Isolate and Assess the Viability of Single Circulating Tumor Cells
نویسندگان
چکیده
منابع مشابه
Tumor Self-Seeding by Circulating Cancer Cells
Cancer cells that leave the primary tumor can seed metastases in distant organs, and it is thought that this is a unidirectional process. Here we show that circulating tumor cells (CTCs) can also colonize their tumors of origin, in a process that we call "tumor self-seeding." Self-seeding of breast cancer, colon cancer, and melanoma tumors in mice is preferentially mediated by aggressive CTCs, ...
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The first report of circulating tumor cells (CTCs) can be traced back to 1869 when Thomas Ashworth, an Australian physician, observed tumor cells in the blood of a patient who succumbed to advanced metastatic cancer. Since then cancer research has proved the critical roles played by CTC in the metastatic spread of carcinomas. In addition, CTCs contain key information of how tumor genotypes evol...
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15 صفحه اولTumor Self-Seeding: Bidirectional Flow of Tumor Cells
Circulating tumor cells are responsible for seeding metastatic growth at distant sites. Kim et al. (2009) now discover that circulating tumor cells can reinfiltrate tumors at their primary organs and promote tumor progression.
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2019
ISSN: 1422-0067
DOI: 10.3390/ijms20030477